Saturday, March 19, 2016

Our Aging Population and Increasing Dependence on Prescription Medicines


As of December 2, 2015, the United States has a total resident population of 322,267,564, making it the third most populous country in the world.

There were about 125.9 million adult women in the United States in 2014. The number of men was 119.4 million. At age 85 and older, there were almost twice as many women as men (4 million vs. 2.1 million). People under 21 years of age made up over a quarter of the U.S. population (27.1%), and people age 65 and over made up one-seventh (14.5%).  The national median age was 36.8 years in 2009.

As of 2012, people are distributed by age as follows:

  • 0–14 years: 19.8% (male 31,639,127/female 30,305,704)
  • 15–64 years: 66.8% (male 101,612,000/female 104,577,000)
  • 65 years and over: 13.4% (male 18,332,000/female 23,174,000) (2012 est.)

America faces an unprecedented challenge. The number of people reaching retirement will double in number by 2030, accounting for an increase from 12 percent of the U.S. population to almost 20 percent.


Population Aged 65 and Over for the United States: 2012 to 2050:

Mortality: Driver of Trends in the Older Population

The size and composition of the older population in 2050 will be largely determined by two factors: the size and composition of the population 27 years and over in 2012 and the future course of mortality for that population. While past fertility rates were the main driver shaping the size of these cohorts to date, mortality will influence the pace at which that population declines at the older ages.

Nearly everyone who will be 65 years and over and living in the United States in 2050 already lives here. No one born after 1985— those 27 and younger in 2012— can add to this population, because they will not be over the age of 65 by 2050. Since most immigrants are projected to be under the age of 40 when they arrive in the United States, international migration will play a limited role in creating the future population over age 65. Future migration will have even less of a role in shaping the future population over age 85.

The 65 and over population is growing, and that certainly is contributing to overall rising rates of prescription drug use; nearly 40 percent of adults 65 and older reported use of five or more medications.  However, 8 of the 10 most commonly used drugs are used to manage heart disease, high blood pressure, diabetes and high cholesterol, all conditions and health complications that may develop as a person gains weight.  

Prescription drug use has increased steadily in the U.S. for the past decade. The percentage of people who took at least one prescription drug in the past month increased from 44 percent in 1999-2000 to 48 percent in 2007-08. Spending on prescription drugs reached $250 billion in 2009 the year studied, and accounted for 12 percent of total personal health care expenditures. Drug-related spending is expected to continue to grow in the coming years.

Overall, women and older adults receive more prescriptions. Vaccines, antibiotics and anti-asthma drugs are most commonly prescribed in people younger than 19. Antidepressants and opioids are most common among young and middle-aged adults. Cardiovascular drugs are most commonly prescribed in older adults. Women receive more prescriptions than men across several drug groups, especially antidepressants: Nearly 1 in 4 women ages 50-64 are on an antidepressant.

Among people older than 60, about 88 percent were using at least one medicine, and more than one-third were taking five or more.

  • About half of all Americans in 2007-2010 reported taking one or more prescription drugs in the past 30 days. Use increased with age; 1 in 4 children took one or more prescription drugs in the past 30 days compared to 9 in 10 adults aged 65 and over.
  • Cardiovascular agents (used to treat high blood pressure, heart disease or kidney disease) and cholesterol-lowering drugs were two of the most commonly used classes of prescription drugs among adults aged 18-64 years and 65 and over in 2007-2010. Nearly 18 percent (17.7) of adults aged 18-64 took at least one cardiovascular agent in the past 30 days.
  • The use of cholesterol-lowering drugs among those aged 18-64 has increased more than six-fold since 1988-1994, due in part to the introduction and acceptance of statin drugs to lower cholesterol.
  • Other commonly used prescription drugs among adults aged 18-64 years were analgesics to relieve pain and antidepressants.
  • The prescribing of antibiotics during medical visits for cold symptoms declined 39 percent between 1995-1996 and 2009-2010.
  • Among adults aged 65 and over, 70.2 percent took at least one cardiovascular agent and 46.7 percent took a cholesterol-lowering drug in the past 30 days in 2007-2010. The use of cholesterol-lowering drugs in this age group has increased more than seven-fold since 1988-1994.
  • Other commonly used prescription drugs among those aged 65 and older included analgesics, blood thinners and diabetes medications.
  • In 2012, adults aged 18-64 years who were uninsured for all or part of the past year were more than four times as likely to report not getting needed prescription drugs due to cost as adults who were insured for the whole year (22.4 percent compared to 5.0 percent).
  • The use of antidepressants among adults aged 18 and over increased more than four-fold, from 2.4 percent to 10.8 percent between 1988-1994 and 2007-2010.
  • Drug poisoning deaths involving opioid analgesics among those aged 15 and over more than tripled in the past decade, from 1.9 deaths per 100,000 population in 1999-2000 to 6.6 in 2009-2010.
  • The annual growth in spending on retail prescription drugs slowed from 14.7 percent in 2001 to 2.9 percent in 2011.

In 2009–2012 compared with 1999–2002, the percentage of adults aged 55–64 who took selected prescription drugs was 54% higher for cholesterol-lowering drugs, 78% higher for gastric reflux drugs, 40% higher for antidepressant drugs, and 29% higher for antidiabetic drugs. In contrast, the percentage of adults aged 55–64 who took prescription cardiovascular agents (which include heart, blood pressure, and kidney drugs) and the percentage who took prescription analgesics were similar to the levels in 1999–2002.

In 2009–2012, nearly one-half (45.0%) of adults aged 55–64 took a prescription cardiovascular drug in the past 30 days, nearly one-third (31.8%) took a prescription cholesterollowering drug, and 16.0% used prescription gastric reflux medications (for anti-acid reflux and stomach ulcers). Fifteen percent of those aged 55–64 used prescription analgesics (narcotics, nonsteroidal anti-inflammatory drugs, and aspirin), and 14.4% used prescription antidepressants in the past 30 days. Antidepressant drugs can be prescribed for a wide variety of clinical reasons. In 2009–2012, 12.9% of those aged 55–64 used prescription antidiabetic agents.

For adults aged 55–64, the percentage who delayed or did not receive needed medical care due to cost in the past 12 months, or who did not receive needed prescription drugs due to cost in the past 12 months, was higher in 2012–2013 than in 2002– 2003 and varied by insurance coverage.
Forgoing or delaying needed health care can have serious health effects (92). Access to care is a complex process that addresses the extent to which a population can connect with health care and reflects the affordability, availability, and acceptability of health services. Health insurance facilitates access to health care by connecting individuals to health care providers and by covering a portion of the cost of care.

In 2012–2013, 13.2% of adults aged 55–64 delayed or did not receive needed medical care in the past 12 months due to cost, 39% higher than in 2002–2003 (9.5%). For adults aged 55–64 who were insured for the entire past year, the percentage who delayed or did not receive needed medical care due to cost was 32% higher in 2012–2013 (7.8%) than in 2002–2003 (5.9%). The percentage of adults aged 55–64 who were uninsured for all or some of the past year and who delayed or did not receive needed medical care due to cost was 14% higher in 2012–2013 (44.2%) compared with 2002–2003 (38.7%).

In 2012–2013, 8.8% of adults aged 55–64 did not receive needed prescription drugs in the past 12 months due to cost, 26% higher than in 2002–2003 (7.0%). For adults who were insured for the entire past year, the percentage who did not receive needed prescription drugs due to cost was 25% higher in 2012–2013 (5.5%) than in 2002–2003 (4.4%). For those who were uninsured for all or part of the year, 26.7% did not receive needed prescription drugs due to cost in 2012–2013, similar to the level in 2002–2003.

An association exists between not receiving needed medical care and prescription drugs due to cost and insurance status. In 2012–2013, for adults aged 55–64, those who were uninsured for some or all of the past year were 5.7 times as likely to delay or not receive needed medical care due to cost and 4.9 times as likely to not receive needed prescription drugs due to cost as those who were continuously insured in the past year.

Startling Statistics

10.7% of hospital admissions in older adults are associated with adverse drug reactions (ADRs)

ADRs cause over 100,000 deaths per year in the United States, making ADRs the fourth leading cause of death in the United States

Older adults are 2.5 times more likely to visit an emergency room due to an ADR than younger individuals
Warfarin, insulin, and digoxin together account for over 1/3 of emergency department visits for ADRs among older adults

About 1 in 3 older persons taking at least 5 medications will experience one adverse drug event each year, and about 2/3 of these patients will require medical attention

Getting the Whole Picture

Elderly comprise 13% of population

Use 25-30% all prescription medications; 25% of nonprescription medications

75% of older adults take one or more prescription medications

25% of older adults take 5 or more medications on a regular basis

Use 5.8 Rx drugs concurrently with 3.2 OTC drugs

The elderly are one of the most fragile patient population and it should be our common goal to dedicate a special attention to their well-being. The elderly represent an extremely heterogeneous patient population that differs significantly in terms of functional capabilities, their morbidity and co-morbidity without any relationship to the numerical age. Due to the increasing probability to develop chronic diseases with age, elderly are the main user group for medicinal products. As such, the medicinal products contribute to the increasing life expectancy of humans and the maintenance of the individual’s health and independence, but unfortunately also to medication related problems.


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